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ebook:Nurse’s Manual of Laboratory and Diagnostic Tests EDITION

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Pyruvate kinase (PK) functions in the formation of
pyruvate and adenosine diphosphate (ADP) in
glycolysis. The pyruvate thus formed is subsequently
converted to lactate. RBCs that lack PK have a low
affinity for oxygen. Episodes of hemolysis in individuals
lacking this enzyme are severe and chronic and
are exacerbated by stressors such as infection.

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