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The Army Medical Department (AMEDD) has made a commitment to establishing a structure and process to support its military treatment facilities (MTFs) in implementing evidence-based practice guidelines with the goal of achieving best practices that reduce variation and enhance quality of medical care. The Quality Management Directorate of the Army Medical Command (MEDCOM) contracted with RAND to…
Abstract Introduction: Nigeria is a developing country that is currently witnessing an upsurge in diabetes mellitus and obesity with its antecedent consequences. There is also a fairly high prevalence of asthma affecting an estimated 10.7% of the population. There is no data presently on the possible presence of metabolic syndrome in Nigerian living with asthma. The study was conceived to dete…
Abstract Introduction: Lactic acidosis often occurs in severely unwell patients presenting to Accident and Emergency. It is commonly associated with either hypoxia or decreased tissue perfusion secondary due to cardiovascular collapse or sepsis. Case presentation: We present a case of severe lactic acidosis in the presence of normal tissue perfusion and oxygenation in a 31-year-old patient…
Abstract Novel treatment strategies are currently emerging for patients with inadequately controlled asthma despite good adherence and trigger avoidance. ese strategies serve primarily to reduce or com-pletely avoid long-term oral corticosteroid therapy. A number of these options have already been imple-mented in practice or will soon be authorized for the treatment of asthma, while others s…
Summary e activation of naive CD4+ and CD8+ T cells in response to antigen and their subsequent prolifera-tion and di erentiation into e ectors are important features of a cell-mediated immune response. CD4+ T cells (also known as T helper cells, ) dif-ferentiate into several subpopulations including 1, 2, 9, 17, T and Treg cells, characterized by speci c cytokine pro les and…
Abstract In the last years there is an increasing trend towards personalized medicine for patients with asthma. is is due to the availability of novel speci c thera-pies. ese new compounds are supposed to be used in well-de ned patient groups, which are likely to respond to these interventions. In addition to already used anti-IgE, novel monoclonal antibodies such as anti-IL-5 and anti-…
Given that all human organs have vitamin D recep-tors, it is not surprising that vitamin D3 de ciency can also cause disease symptoms in the lungs. Known diseases include productive and obstructive bronchitis, asthma, chronic obstructive pulmonary disease (COPD), and frequent respiratory infections [1, 2]. To date, there is insu cient data to support whether vitamin D replacementimproves the…