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SQL ⚙️: array:2 [ "count" => "select count(distinct b.biblio_id) from biblio as b left join mst_publisher as mp on b.publisher_id=mp.publisher_id left join mst_place as mpl on b.publish_place_id=mpl.place_id where b.opac_hide=0 and (b.biblio_id in(select bt.biblio_id from biblio_topic as bt left join mst_topic as mt on bt.topic_id=mt.topic_id where mt.topic like ?))" "query" => "select b.biblio_id, b.title, b.image, b.isbn_issn, b.publish_year, mp.publisher_name as `publisher`, mpl.place_name as `publish_place`, b.labels, b.input_date, b.edition, b.collation, b.series_title, b.call_number from biblio as b left join mst_publisher as mp on b.publisher_id=mp.publisher_id left join mst_place as mpl on b.publish_place_id=mpl.place_id where b.opac_hide=0 and (b.biblio_id in(select bt.biblio_id from biblio_topic as bt left join mst_topic as mt on bt.topic_id=mt.topic_id where mt.topic like ?)) order by b.last_update desc limit 10 offset 860" ]
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Abstract A relevant proportion of allergy diagnosis is accom-plished by in vitro determination of specic im-munglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycopro-teins, which may react with patients’IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-…
Omalizumab (Xolair®), a humanized monoclonal antibody against human immunoglobulin E (IgE), was recently approved as an add-on therapy for chronic spontaneous urticaria (csU) refractory to treatment in patients aged 12 years and above. e dose in this indication is 300 mg subcutaneously every 4 weeks. is dose was administered to pa-tients showing an inadequate response despite re peated sys…
Atopic dermatitis (AD) represents a pruritic, non-contagious, chronic or chronically relapsing, inammatory skin disease. e course of the dis-ease may be complicated by bacterial or viral super-infections. e rst manifestation of the disease and further are-ups are due to genetic predisposition and also to a variety of further trigger factors. e therapy regimen should be adapted to disease…
Abstract e pork-cat syndrome is an IgE-mediated allergy to pork triggered by a primary sensitization to cat dander. IgE-antibodies are directed to cat serum albumin, Fel d 2, and cross-react with porcine se-rum albumin. In contrast to meat anaphylaxis caused by IgE to α-Gal, in patients with pork-cat syndrome, symptoms occur in less than two hours aer consumption. As albumin is a thermola…
Allergy to poultry meat is rare and aects both chil-dren and adults. e prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. ere is no close relation-ship between allergy to poultry meat and allergy to red meat. Poultry meat allergy may present as pri-mary (genuine) food allergy or as secondary food allergy resulting from cross-reactivity.…
Contact urticaria und contact urticaria syndrome are characterized by the immediate development of itchy ares and wheals [1]. Contact urticaria may turn into contact anaphylaxis and may occur aer topical application of cosmetics, medical ointments, hair dyes, fresh food, metals, and occupational sub-stances such as cow dander, natural rubber latex, or our, grains, and feed [1, 2]. Contact ana…
Abstract e term α-Gal syndrome describes a novel IgE-me-diated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classication as a syndrome is proposed on the basis of its clini-cal relevance in three dierent elds of allergy: food, drugs, and tick bites. e main focus of the present article is on α-Gal as an eliciting allergen in food allergy. It was r…
Summary In the last decade, a novel type of food allergy pre-senting with severe allergic reactions several hours aer consumption of red meat has been recognized. e allergic responses are due to IgE antibodies directed against the carbohydrate epitope galactose-α-1,3- galactose (α-Gal) found in mammalian meat. is review presents the red meat allergy syndrome in Sweden, discusses the feat…
Abstract IgE antibodies to carbohydrate epitopes on aller-gens are thought to be less common than IgE anti-bodies to protein epitopes and also of much less clinical signicance. Our recent work, however, has identied a novel IgE antibody response to a mammalian oligosaccharide epitope, galactose- alpha-1,3-galactose (alpha-gal). IgE to alpha-gal has been associated with two distinct forms of …
Abstract e recently published S2k-guideline on (allergen-) specic immunotherapy (AIT) provides an excel-lent overview of the evidence on allergen prepara-tions available for AIT in Germany based on the published ecacy studies. Publications based on the guideline are currently being used by the Ger-man associations of statutory health insurance physicians and German health insurance funds t…