/var/www/fkik/app/lib/SearchEngine/DefaultEngine.php:610 "Search Engine Debug 🔎 🪲"
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SQL ⚙️: array:2 [ "count" => "select count(distinct b.biblio_id) from biblio as b left join mst_publisher as mp on b.publisher_id=mp.publisher_id left join mst_place as mpl on b.publish_place_id=mpl.place_id where b.opac_hide=0 and (b.biblio_id in(select bt.biblio_id from biblio_topic as bt left join mst_topic as mt on bt.topic_id=mt.topic_id where mt.topic like ?))" "query" => "select b.biblio_id, b.title, b.image, b.isbn_issn, b.publish_year, mp.publisher_name as `publisher`, mpl.place_name as `publish_place`, b.labels, b.input_date, b.edition, b.collation, b.series_title, b.call_number from biblio as b left join mst_publisher as mp on b.publisher_id=mp.publisher_id left join mst_place as mpl on b.publish_place_id=mpl.place_id where b.opac_hide=0 and (b.biblio_id in(select bt.biblio_id from biblio_topic as bt left join mst_topic as mt on bt.topic_id=mt.topic_id where mt.topic like ?)) order by b.last_update desc limit 10 offset 860" ]
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Omalizumab (Xolair®), a humanized monoclonal antibody against human immunoglobulin E (IgE), was recently approved as an add-on therapy for chronic spontaneous urticaria (csU) refractory to treatment in patients aged 12 years and above. e dose in this indication is 300 mg subcutaneously every 4 weeks. is dose was administered to pa-tients showing an inadequate response despite re peated sys…
Atopic dermatitis (AD) represents a pruritic, non-contagious, chronic or chronically relapsing, inammatory skin disease. e course of the dis-ease may be complicated by bacterial or viral super-infections. e rst manifestation of the disease and further are-ups are due to genetic predisposition and also to a variety of further trigger factors. e therapy regimen should be adapted to disease…
Abstract e pork-cat syndrome is an IgE-mediated allergy to pork triggered by a primary sensitization to cat dander. IgE-antibodies are directed to cat serum albumin, Fel d 2, and cross-react with porcine se-rum albumin. In contrast to meat anaphylaxis caused by IgE to α-Gal, in patients with pork-cat syndrome, symptoms occur in less than two hours aer consumption. As albumin is a thermola…
Allergy to poultry meat is rare and aects both chil-dren and adults. e prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. ere is no close relation-ship between allergy to poultry meat and allergy to red meat. Poultry meat allergy may present as pri-mary (genuine) food allergy or as secondary food allergy resulting from cross-reactivity.…
Contact urticaria und contact urticaria syndrome are characterized by the immediate development of itchy ares and wheals [1]. Contact urticaria may turn into contact anaphylaxis and may occur aer topical application of cosmetics, medical ointments, hair dyes, fresh food, metals, and occupational sub-stances such as cow dander, natural rubber latex, or our, grains, and feed [1, 2]. Contact ana…
Abstract e term α-Gal syndrome describes a novel IgE-me-diated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classication as a syndrome is proposed on the basis of its clini-cal relevance in three dierent elds of allergy: food, drugs, and tick bites. e main focus of the present article is on α-Gal as an eliciting allergen in food allergy. It was r…
Summary In the last decade, a novel type of food allergy pre-senting with severe allergic reactions several hours aer consumption of red meat has been recognized. e allergic responses are due to IgE antibodies directed against the carbohydrate epitope galactose-α-1,3- galactose (α-Gal) found in mammalian meat. is review presents the red meat allergy syndrome in Sweden, discusses the feat…
Abstract IgE antibodies to carbohydrate epitopes on aller-gens are thought to be less common than IgE anti-bodies to protein epitopes and also of much less clinical signicance. Our recent work, however, has identied a novel IgE antibody response to a mammalian oligosaccharide epitope, galactose- alpha-1,3-galactose (alpha-gal). IgE to alpha-gal has been associated with two distinct forms of …
Abstract e recently published S2k-guideline on (allergen-) specic immunotherapy (AIT) provides an excel-lent overview of the evidence on allergen prepara-tions available for AIT in Germany based on the published ecacy studies. Publications based on the guideline are currently being used by the Ger-man associations of statutory health insurance physicians and German health insurance funds t…
Abstract Novel treatment strategies are currently emerging for patients with inadequately controlled asthma despite good adherence and trigger avoidance. ese strategies serve primarily to reduce or com-pletely avoid long-term oral corticosteroid therapy. A number of these options have already been imple-mented in practice or will soon be authorized for the treatment of asthma, while others s…