Artikel

Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues

---

AbstractStrong evidence implicatesmaternal environmental exposures in contributing to adverse outcomes during preg-nancy and later in life through the developmental origins of health and disease hypothesis. Recent research suggests these effects are mediated through the improper regulation of DNA methylation in offspring tissues, specifically placental tissue, which plays a critical role in fetal development. This article reviews the relevant literature relating DNA methylation in multiple tissues at or near delivery to several prenatal environ-mental toxicants and stressors, including cigarette smoke, en-docrine disruptors, heavy metals, as well as maternal diet. These human studies expand upon previously reported out-comes in animal model interventions and include effects on both imprinted and non-imprinted genes. We have also noted some of the strengths and limitations in the approaches used, and consider the appropriate interpretation of these findings in terms of their effect size and their relationship to differential gene expression and potential health outcomes. The studies suggest an important role of DNA methylation in mediating the effects of the intrauterine environment on children’shealth and a need for additional research to better clarify the role of this epigenetic mechanism as well as others.

---

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

-

No. Panggil

Artikel

Penerbit

USA : Springer., 2015

Deskripsi Fisik

-

Bahasa

English

ISBN/ISSN

DOI 10.1007/s40572-0

Klasifikasi

NONE

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

Curr Envir Health Rpt (2015) 2:126–136

Subjek

Prenatal
DNA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar