Artikel

Analytical Complexity in Detection of Gene Variant-by-Environment Exposure Interactions in High-Throughput Genomic and Exposomic Research

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AbstractIt seems intuitive that disease risk is influenced by the interaction between inherited genetic variants and environ mental exposure factors; however, we have few documented interactions between variants and exposures. Advances in technology may enable the simultaneous measurement (i.e., on the same individuals in an epidemiological study) of mil-lions of genome variants with thousands of environmental Bexposome^factors, significantly increasing the number of possible factor pairs available for testing for the presence of interactions. The burden of analytic complexity, or sheer num-ber of genetic and exposure factors measured, poses a consid-erable challenge for discovery of interactions in population scale data. Advances in analytic approaches, large sample sizes, less conservative methods to mitigate multiple testing, and strong biological priors will be required to prune the search space to find reproducible and robust gene-by-environment interactions in observational data.

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2016

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s40572-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Curr Envir Health Rpt (2016) 3:64–72

Subjek

Medicine
Exposure
Analytical Complexity

Info Detail Spesifik

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Pernyataan Tanggungjawab

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