Artikel

Orquestic regulation of neurotransmitters on reward-seeking behavior

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Abstract
The ventral tegmental area is strongly associated with the reward system. Dopamine is released in areas such as the nucleus accumbens and prefrontal cortex as a result of rewarding experiences such as food, sex, and neutral stimuli that become associated with them. Electrical stimulation of the ventral tegmental area or its output pathways can itself serve as a potent reward. Different drugs that increase dopamine levels are intrinsically rewarding. Although the dopaminergic system represent the cornerstone of the reward system, other neurotransmitters such asendogenous opioids, glutamate,γ-Aminobutyric acid, acetylcholine, serotonin, adenosine, endocannabinoids, orexins, galanin and histamine all affect this mesolimbic dopaminergic system. Consequently, genetic variations of neurotransmission are thought influence reward processing that in turn may affect distinctive social behavior and susceptibility to addiction. Here, we discuss current evidence on the orquestic regulation of different neurotranmitters on reward-seeking behavior and its potential effect on drug addiction.
Keywords:Dopamine, Orexin, Serotonin, Galanin, Histamine, Endocannabinoids, Reward-seeking behavior, Drug addiction

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

Mexico : Springer., 2014

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

doi:10.1186/1755-768

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

International Archives of Medicine2014,7:29

Subjek

Medicine
neurotransmitters
reward-seeking behavior

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