Artikel

A software tool for the analysis of neuronal morphology data

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Abstract
Anatomy plays a fundamental role in supporting and shaping nervous system activity. The remarkable progress of computer processing power within the last two decades has enabled the generation of electronic databases of complete three-dimensional (3D) dendritic and axonal morphology for neuroanatomical studies. Several laboratories are freely posting their reconstructions online after result publicationv.gr.NeuroMorpho.Org (Nat Rev Neurosci 7:318–324, 2006). These neuroanatomical archives represent a crucial resource to explore the relationship between structure and function in the brain (Front Neurosci6:49, 2012). However, such‘Cartesian’ descriptions bear little intuitive information for neuroscientists. Here, we developed a simple prototype of a MATLAB-based software tool to quantitatively describe the 3D neuronal structures from public repositories. The program imports neuronal reconstructions and quantifies statistical distributions of basic morphological parameters such as branch length, tortuosity, branch's genealogy and bifurcation angles. Using these morphological distributions, our algorithm can usable for network simulations.
Keywords:Neurons, Dendrites, Morphology, Tortuosity, Simulations

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

Mexico : Springer., 2014

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

doi:10.1186/1755-768

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

International Archives of Medicine2014,7:6

Subjek

Medicine
ool for the analysis of
neuronal morphology

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