Artikel
Use of Systematic Review and Meta-Analysis in Environmental Health Epidemiology: a Systematic Review and Comparison with Guidelines
AbstractSystematic review (SR) and meta-analysis (MA) have potential to contribute substantially to environmental health (EH) risk assessment and policy-making, provided study questions are clear and methods sound. We undertook
a systematic review of the published epidemiological litera-ture for studies using both SR andMAexamining associations between chronic low-dose chemical exposures and adverse health outcomes in general populations and compared actual
methods and reporting with a checklist based on available published guidelines. We identified 48 EH SRMAs meeting these criteria. Associations were mainly positive and statisti-cally significant, often involving large populations. A majority of studies followed most general SRMA guidance, although we identified weaknesses in problem formulation, study search, selection and data extraction, and integrating policy implications. Fewer studies followed EH-specific SRMA rec-ommendations, particularly regarding exposure heterogeneity and other risks of bias. Development and adoption of EH-specific SRMA guidelines would contribute to mstrengthening these tools for public health decision-making. Keywords Systematic review. Meta-analysis. Environmental health. Reporting guidelines.Air pollution.
Environmental epidemiology
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