Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-a | Perpustakaan Fakultas Kedokteran dan Ilmu Kesehatan

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Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-a

Puertas-Abreu, Eduardo - Nama Orang; Elaudi Rodríguez Polanco - Nama Orang; Miriam Azocar - Nama Orang; Luis Antonio Mundarai - Nama Orang; Concepción Morelia Nuñez-Sotel - Nama Orang;

Abstract
Background:The anti-TNFatherapy has been since its approval by the FDA, along with nonsteroidal antiinflammatory drugs (NSAIDs), one of the most important therapies for control of spondyloarthritis (SpA). The onset of Lupus Like Syndrome (LLS) has been described in patients with rheumatoid arthritis (RA) treated with anti-TNFatherapy but there is little literature on the occurrence of this entity in patients with SpA.
Methods:We studied 57 patients with SpA who received more than 1 year of anti-TNFatherapy (infliximab, adalimumab or etanercept). Patients were analyzed for the development of LLS, in addition to measuring ANA levels ≥1:160 and Anti-dsDNA (measured by IIF).
Results:In total, 7.01% of patients treated with anti-TNFahad titers of ANA≥1:160, whereas 3.5% of patients had serum levels of dsDNA. However, only one patient (1.75%; n = 1) experienced clinical symptoms of LLS; this was a female patient with a history of psoriatic arthritis.
Conclusions:The presence of LLS secondary to anti-TNFatherapy in patients with SpA is observed less frequently compared with patients with RA. LLS was only detected in a patient with a history of psoriasis since youth, who developed psoriatic arthritis after 27 years of age and had received anti-TNFatherapy for > 2 years. This may be because LLS is an entity clearly associated with innate immunity, with little central role of B and T cells.
Keywords:Antinuclear antibodies, Lupus-like syndrome, Anti-TNFa?α? therapy, Anti-dsDNA, Psoriasis

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Informasi Detail

Judul Seri: -
No. Panggil: Artikel
Penerbit: Venezuela : Springer., 2012
Deskripsi Fisik: -
Bahasa: English
ISBN/ISSN: doi:10.1186/1755-768
Klasifikasi: NONE
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: International Archives of Medicine 2012,5:7
Subjek: Medicine
lupus like syndrome
spondyloarthritis treated
anti-TNF-a
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-a

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