Artikel
Histone Modification Patterns and Their Responses to Environment
AbstractHistone modifications play important roles in the epigenetic regulation of gene expression. Recent genome-wide profiling of histone modifications with deep sequencing-based methods provides novel insights of crosstalk between histone modifications, leading to recent proposals of histone “language”or“web”as an alternative of“code”to appreciate combinatorial modification patterns. Environmental factor–al-tered histonemodifications now may be addressed dynamically and systematically with the recognition and use of these inter-esting combinatorial patterns. Keywords Histone code.Histonemethylation.Histone acetylation.Gene transcription.ChIP-seq. Environmental factors. Histone modification patterns
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