Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases | Perpustakaan Fakultas Kedokteran dan Ilmu Kesehatan

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Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases

Wernicke, Caroline M - Nama Orang; Thomas GP Grunewald - Nama Orang; Juenger Hendrik - Nama Orang; Selim Kuci - Nama Orang; Zyrafete Kuci - Nama Orang;

Abstract
Severe acute graft versus host disease (GvHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. Human mesenchymal stromal cells (MSCs) play an important role in endogenous tissue
repair and possess strong immune-modulatory properties making them a promising tool for the treatment of steroid-refractory GvHD. To date, a few reports exist on the use of MSCs in treatment of GvHD in children indicating that children tend to respond better than adults, albeit with heterogeneous results. We here present a review of the literature and the clinical course of two instructive pediatric patients with acute steroid-refractory GvHD after haploidentical stem cell transplantation, which exemplify the beneficial effects of third-party transplanted MSCs in treatment of acute steroid-refractory GvHD. Moreover, we provide a meta-analysis of clinical studies addressing the outcome of patients with steroid-refractory GvHD and treatment with MSCs in adults and in children (n = 183; 122 adults, 61 children). Our meta-analysis demonstrates that the overall response-rate is high (73.8%) and confirms, for the first time, that children indeed respond better to treatment of GvHD with MSCs than adults (complete response 57.4% vs. 45.1%, respectively). These data emphasize the significance of this therapeutic approach especially in children and indicate that future prospective studies are needed to assess the reasons for the observed differential response-rates in pediatric and adult patients

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Judul Seri: -
No. Panggil: Artikel
Penerbit: German : Springer., 2011
Deskripsi Fisik: -
Bahasa: English
ISBN/ISSN: doi:10.1186/1755-768
Klasifikasi: NONE
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: International Archives of Medicine 2011,4:27
Subjek: Medicine
Mesenchymal stromal
steroid-refractory GvHD
pediatric
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases

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