Artikel

Granulocytic sarcoma of the small bowel, greater omentum and peritoneum associated with a CBFb/MYH11 fusion and inv(16) (p13q22): a case report

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Abstract
Introduction: Granulocytic sarcoma (GS) is an extramedullary disease which is composed of immature myeloid
cells or myeloblasts and usually occurs in association with acute myeloid leukemia (AML), as an initial presentation or a relapse. GS has been associated with various cytogenetic abnormalities, particularly with the t(8;21) translocation and less frequently the inv(16) type.
Case presentation: We present a rare case of GS of the small bowel, greater omentum and peritoneum, which
caused obstruction, in a patient with AML associated with a CBFb/MYH11 fusion gene and an inv(16) (p13q22). In
this patient there was only mild myeloid hyperplasia in bone marrow aspiration but molecular analysis identified a CBFb-MYH11 fusion and inv(16) (p13;q22).
Conclusion: Because of its nonspecific clinical and radiologic findings, this entity can be misdiagnosed and can mimic other solid neoplasms, making it a diagnostic challenge. In a GS with no or minimal morphological changes in bone marrow aspiration it is very important to perform a cytogenetic analysis to benefit from the diagnosis and therapeutic strategy.

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Judul Seri

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No. Panggil

Artikel

Penerbit

Spain : Springer., 2011

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

doi:10.1186/1755-768

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

International Archives of Medicine 2011, 4:3

Subjek

Medicine
Granulocytic sarcoma
greater omentum
peritoneum
CBFb/MYH11 fusion
inv(16) (p13q22)

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