Artikel

Arsenic Exposure and Subclinical Endpoints of Cardiovascular Disease

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AbstractMechanistic evidence suggests that arsenic expo-sure from drinking water increases the production of reactive oxygen species and influences inflammatory responses and endothelial nitric oxide homeostasis. These arsenic-induced
events may lead to endothelial dysfunction that increases the risk of atherosclerosis and cardiovascular disease. We reviewed accumulating epidemiologic evidence that evaluated the association between arsenic exposure and intermediate markers and subclinical measures that predict future cardio vascular risk. Cross-sectional studies have indicated positive associations between high or low-to-moderate levels of arse-nic exposure with indices of subclinical atherosclerosis, QT interval prolongation, and circulating markers of endothelial dysfunction. The evidence is limited for other intermediate endpoints such as markers of oxidative stress and inflamma-tion, QT dispersion, and lipid profiles. Prospective studies are needed to enhance the causal inferences of the effects of arsenic on subclinical endpoints of cardiovascular disease, especially at lower arsenic exposure levels. Keywords Arsenic exposure.Cardiovascular disease. Subclinical atherosclerosis.QTc prolongation.Oxidative stress .Inflammation .Endothelial dysfunction. Susceptibility

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2014

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s40572-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Curr Envir Health Rpt (2014) 1:148–162

Subjek

Medicine
Arsenic Exposure
Cardiovascular Disease

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