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The case for too little melatonin signalling in increased diabetes risk

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Abstract Genome-wide association studies have detected an associationbetweentype2diabetesriskandanon-codingSNP located in MTNR1B, the gene encoding melatonin receptor 2 (MT2). Melatonin regulates circadian rhythms and sleep and associateswithmetabolicdisorders.However,themechanisms underlying these actions are still unclear. Functional genomic, animal and clinical studies have not reached the same conclusions: while some studies have reported that decreased melatonin signalling increases type 2 diabetes risk, others have found the opposite. In this commentary, we have tried to provide an explanation for these contradictions and we suggest how the communitymayprogresstoreachaunifiedpictureoftheeffect of melatonin and its signalling on type 2 diabetes.
Keywords eQTL .Genome-wideassociationstudy .GWAS . Melatonin .Melatoninreceptor .MTNR1B/MT2 .Pancreatic islets .Rarevariants .Sequencing .SNP

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2017

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s00125-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Diabetologia (2017) 60:823–825

Subjek

Medicine
melatonin signalling

Info Detail Spesifik

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