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Precision diabetes: learning from monogenic diabetes

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Abstract The precision medicine approach of tailoring treatment to the individual characteristics of each patient or subgroup has been a great success in monogenic diabetes subtypes, MODY and neonatal diabetes. This review examines what has led to the success of a precision medicine approach in monogenic diabetes (precision diabetes) and outlines possibleimplicationsfortype2diabetes.Formonogenicdiabetes, the molecular genetics can define discrete aetiological subtypes that have profound implications on diabetes treatment and can predict future development of associated clinical features, allowing early preventative or supportive treatment. In contrast, type 2 diabetes has overlapping polygenic susceptibility and underlying aetiologies, making it difficult to define discreteclinicalsubtypeswithadramaticimplicationfortreatment. The implementation of precision medicine in neonatal diabetes was simple and rapid as it was based on single clinical criteria (diagnosed

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2017

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s00125-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Diabetologia (2017) 60:769–777

Subjek

Medicine
monogenic diabetes

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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