Bisphosphonates adherence for treatment of osteoporosis | Perpustakaan Fakultas Kedokteran dan Ilmu Kesehatan

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Bisphosphonates adherence for treatment of osteoporosis

Vieira, Helena Parente - Nama Orang; Ingrid Almeida Leite - Nama Orang; Thayga Maria Araújo Sampaio - Nama Orang; Juliane dos Anjos de Paula - Nama Orang; Ankilma do Nascimento Andrade - Nama Orang;

Abstract
Background: Osteoporosis is a disease of bone metabolism in which bisphosphonates (BPS) are the most common medications used in its treatment, whose main objective is to reduce the risk of fractures. The aim of this study was to conduct a systematic review on BPs adherence for treatment of osteoporosis.
Methods: Systematic review of articles on BPs adherence for treatment of osteoporosis, indexed on MEDLINE (via PubMed) databases, from inception of databases until January 2013. Search terms were “Adherence, Medication” (MeSH term), “Bisphosphonates” (MeSH term), and “Osteoporosis” (MeSH term).
Results: Of the 78 identified studies, 27 met the eligibility criteria. Identified studies covered a wide range of aspects regarding adherence and associated factors, adherence and fracture, adherence and BPs dosage. The studies are mostly observational, conducted with women over 45 years old, showing low rates of adherence to treatment. Several factors may influence adherence: socio-economic and cultural, participation of physicians when guidance is given to the patient, the use of bone turnover markers, and use of generic drugs. The monthly dosage is associated with greater adherence compared to weekly dosage.
Conclusions: Considering the methodological differences between the studies, the results converge to show that adherence to treatment of osteoporosis with BPs is still inadequate. Further experimental studies are needed to evaluate the adherence and suggest new treatment options.

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Informasi Detail

Judul Seri: -
No. Panggil: Artikel
Penerbit: Brazil : Springer., 2013
Deskripsi Fisik: -
Bahasa: English
ISBN/ISSN: doi:10.1186/1755-768
Klasifikasi: NONE
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: International Archives of Medicine 2013, 6:24
Subjek: Osteoporosis
Medicine
Bisphosphonates
adherence
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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