Salivary VEGF: a non-invasive angiogenic and lymphangiogenic proxy in head and neck cancer prognostication | Perpustakaan Fakultas Kedokteran dan Ilmu Kesehatan

Pencarian berdasarkan :

SEMUA Pengarang Subjek ISBN/ISSN Pencarian Spesifik

Pencarian terakhir:

Image of Salivary VEGF: a non-invasive angiogenic and lymphangiogenic proxy in head and neck cancer prognostication

Artikel

Salivary VEGF: a non-invasive angiogenic and lymphangiogenic proxy in head and neck cancer prognostication

Upile, Tahwinder - Nama Orang; Panagiotis Kafas - Nama Orang; Colin Hopper - Nama Orang; Waseem Jerjes - Nama Orang; Sandeep U Singh - Nama Orang; Holger Sudhoff - Nama Orang; Shash Hirani - Nama Orang; Marcel Guyer - Nama Orang; Melissa Bentley - Nama Orang;

Abstract
Background: Saliva is an enriched milieu containing biologically active proteins, including growth factors and cytokines. The endothelial growth factor family of proteins is important for the development of blood and lymphatic vessels in a healthy individual but also can aide tumour growth. The aim of this study is to develop an independent normative database of values of salivary VEGF in a healthy population and to test the hypothesis that values would be raised in the saliva of patients with oral cancer.
Methods: Twenty-one participants (12 males and 9 females) of whom 14 were healthy and 7 had oral squamous cell carcinoma took part in this study. An immunoassay was employed to quantify a range of specific vascular endothelial and lymphatic endothelial growth factors in various body fluid compartments (blood, saliva). This was correlated to tumour factors and patient outcomes.
Results: The mean salivary levels and serum VEGF A165 levels were significantly correlated in the sample as a whole. Additionally, both saliva and serum VEGF A165 levels were significantly correlated with age. There were significant differences in the salivary and serum levels of the control group and the cancer group.
Conclusion: We present independent normative data on the levels of endothelial growth factor in the saliva of a healthy control population. We also suggest the use of simple non-invasive tests in helping to predict head and neck tumour biology and outcomes.

Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri: -
No. Panggil: Artikel
Penerbit: German : Springer., 2009
Deskripsi Fisik: -
Bahasa: English
ISBN/ISSN: doi:10.1186/1755-768
Klasifikasi: NONE
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: International Archives of Medicine 2009, 2:12
Subjek: Medicine
Salivary VEGF
a non-invasive angiogenic
lymphangiogenic
head and neck
cancer prognostication
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas

Salivary VEGF: a non-invasive angiogenic and lymphangiogenic proxy in head and neck cancer prognostication

Komentar

Anda harus masuk sebelum memberikan komentar