Artikel

Plasmatic level of neurosin predicts outcome of mild cognitive impairment

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Abstract
Background: Mild Cognitive Impairment (MCI) is a disorder considered to be a transitional stage from
health to dementia. Diagnosis of dementias at these early stages is always troublesome because the
pathophysiologic events leading to dementia precede clinical symptoms. Thus, the development of biomarkers that can be used to support the diagnosis of dementias at early stages is rapidly becoming a high priority. We have recently reported the value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease (AD). The aim of this study is to determine whether measuring plasmatic concentration of neurosin is a valuable test to predict progression of MCI.
Methods: Plasmatic neurosin concentrations were measured in 68 MCI patients and 70 controls subjects. Blood samples were obtained at the beginning of the study. Sixty six patients diagnosed with MCI were observed for 18 months. In 36 patients a second blood sample was obtained at the endpoint.
Results: The mean value of plasmatic neurosin concentration differs significantly between MCI patients who converted to Dementia with vascular component, those who converted to AD, or those who
remained at MCI stage. The relative risk of developing Dementia with vascular component when neurosin levels are higher than 5.25 ng/ml is 13 while the relative risk of developing mild AD when neurosin levels are lower than 5.25 ng/ml is 2. Increases in the levels of neurosin indicate progression to Dementia with vascular component.
Conclusion: The measurement of plasmatic neurosin level in patients diagnosed with MCI may predict
conversion from MCI to Dementia with vascular component. A single measurement is also valuable to
estimate the risk of developing AD and Dementia with vascular component. Finally, repeated
measurement of plasmatic neurosin might be a useful test to predict outcome in patients with MCI.

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

Spain : Springer., 2008

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

doi:10.1186/1755-768

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

International Archives of Medicine 2008, 1:11

Subjek

Medicine
Plasmatic
neurosin

Info Detail Spesifik

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Pernyataan Tanggungjawab

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