Artikel

Microbiota, regulatory T cell subsets, and allergic disorders

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Abstract Epidemiologic studies revealed a crucial role of the environment for the increased prevalence of allergic disorders. e microbiota as part of our immediate environment promotes immune diversity that facilitates a well-equilibrated balance between immunity and tolerance. Alterations of our symbiotic microbiota especially in early life is thought to play a fundamental role in dening susceptibility to the development of allergic diseases during adult life on the population level. Due to a high density of bacteria, viruses and fungi and a large contact surface area for host-microbiota interactions, the most relevant interaction between microbes and our immune system are thought to occur in the gut. e immune system co-evolved with the symbiotic microbiota and adopted a variety of mechanisms to allow a dynamic state of tolerance, including the induction of regulatory T cells (Tregs). Foxp3-expressing Tregs are welldescribed immune regulators in autoimmune and allergic disorders. However, recent years have shown that Tregs can come in di­erent €avours with di­erent regulatory potential and outcome for our immune system. is review summarizes novel ndings from basic immunology research that may help to better understand the interaction between the microbiota, di­erentiation of Tregs and its consequences for the onset and regulation of allergic disorders.

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

German : Springer., 2016

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI: 10.1007/s40629-

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Allergo J Int 2016; 25: 114–23

Subjek

Medicine
Microbiota
allergic disorders

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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