Artikel

Epigenetic determinants of allergy and tolerance

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Not only genetics and environmental factors are re-sponsible for the development of allergies. Epigenetic mechanisms – that are master regulators of gene transcription and thus of the accessibility and use of genome information – have been identied as a third power that is key in determining many features of
allergy. So far, three epigenetic mechanisms have been identied in humans: histone modication, DNA methylation, and posttranscriptional modi-cation by microRNA (miRNA) or small interfering RNA (siRNA). In recent years, it became clear that epigenetic regulation of gene function does not only play a role in the development of allergy but may also play a key role in the induction of tolerance against allergens, holding the promise to truly heal or pre-vent atopic diseases in the future.

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2016

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI: 10.1007/s40629-

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Allergo J Int 2016; 25:154–9

Subjek

Medicine
Allergy
Epigenetic

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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