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Effect of salpingectomy, ovarian cystectomy and unilateral salpingo-oopherectomy on ovarian reserve
Abstract Pelvic surgery can affect ovarian reserve, but esti-mates of the potential effect of different surgical procedures are lacking. This study examines the markers of ovarian re-serve after different procedures in order to help the provision of informed consent before surgery. Anti-Müllerian hormone (AMH), antral follicle count (AFC) and follicle-stimulating hormone (FSH) of women with a history of salpingectomy,
ovarian cystectomy or unilateral salpingo-oophorectomywere compared to those without history of surgery using cross-sectional data adjusting for patient and clinical factors in mul-tivariable regression model. There were 138 women who had had salpingectomy, 36 unilateral salpingo-oopherectomy, 41 cystectomy for ovarian cysts that are other than endometrioma and 40 women had had excision of endometrioma. There was no significant difference inAMH (9%;p=0.33),AFC(−2%; p= 0.59) or FSH (−14%;p= 0.21) inwomenwith a history of salpingectomy compared to women without surgery. Women with a history of unilateral salpingo-oophorectomy were found to have significantly lower AMH (−54 %;p=0.001). These women also had lower AFC (−28 %;p= 0.34) and higher FSH (14%;p= 0.06), the effect of which did not reach statistical significance. The study did not find any significant associations between a history of cystectomy, for disease other than endometrioma and AMH (7 %; p= 0.62), AFC (13 %; p= 0.18) or FSH. (11 %;p= 0.16). Women with a history of cystectomy for ovarian endometrioma had 66 % lower AMH (p= 0.002). Surgery for endometrioma did not significantly affect AFC (14 %;p= 0.22) or FSH (10 %;p=0.28). Salpingo-oopherectomy and cystectomy for endometrioma cause a significant reduction in AMH levels. Neither salpingectomy nor cystectomy for cysts other than endometrioma has appreciable effects on ovarian reserve.
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