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Recombinant allergens in speciFIc immunotherapy

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Abstract Allergens produced by recombinant DNA technol-ogy have the ability to improve allergy diagnosis and are used as reference standards for analytical methods. In addition, the use of recombinant aller-gens in specic immunotherapy has long been con sidered potentially superior compared with the use of conventional extracts. e advantages are clear: a complex natural substance that is dicult to char-acterize is replaced by only those components rele-vant for treatment, which furthermore can be re-produced in pharmaceutical quality. e challenges faced here include selecting the relevant allergen molecules and establishing a manufacturing that meets all the regulatory requirements for marketing authorization. In addition to unmodied recombi-nant allergens, hypoallergenic variants with lower IgE reactivity can also be made by genetic engineer-ing. Proof of concept has been demonstrated for both these approaches in clinical trials

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Ketersediaan

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

German : Springer., 2015

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI: 10.1007/s40629-

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Allergo J Int 2015; 24: 143–51

Subjek

Medicine
Immunotherapy
Allergens

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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