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Occupational allergy to β-lactam antibiotics
Contact urticaria in atopic patients was described by Hannuksela [1], among others, in 1980. It gener-ally appears within 30 min of allergen contact and, in the majority of cases, is restricted to the areas of contact; however, local spread and generalized ur-ticaria in the sense of anaphylaxis are seen. Allergic rhinoconjunctivitis and asthma may also subse-quently occur [2]. Von Krogh and Maibach [3] sub-divide contact urticaria into four degrees of sever-ity: Grade I and II are restricted to the skin, i. e., lo-calized urticaria (Stage I) and generalized urticaria (Stage II). Extracutaneous and systemic reactions (asthma, rhinitis, conjunctivitis, orolaryngeal symptoms, and gastrointestinal symptoms) are characterized as Grade III, and Grade IV refers to anaphylactic reactions. e prevalence of contact urticaria among healthcare workers is not known. It varies in Europe from 5 % to 10 %, whereas be-tween 1 % and 3 % of the normal population in Rus-sia is believed to be a ected [4]. In the case of regu-lar contact, the prevalence of sensitization to drugs increases with working years (6.7 % a er 1 year vs. 47 % a er 7 years) [5]. e prevalence of occupational allergy to natural rubber latex in the 1990s was 8 %–17 % [6].
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