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The prevalence of occult leiomyosarcoma at surgery for presumed uterine fibroids: a meta-analysis

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AbstractThere is a concern regarding the risk of occult
leiomyosarcomas found at surgery for presumed benign fi-broids. We sought to produce a comprehensive reviewof pub-lished data addressing this issue and provide high-quality prevalence estimates for clinical practice and future research. A comprehensive literature search using the PubMed/ database and the Cochrane Library was per-formed. Inclusion criteria were human studies, peer-reviewed, with original data, involving cases for surgery in which fibroid-related indications were the primary reason for sur-gery, and histopathology was provided. Candidate studies (4864) were found; 3844 were excluded after review of the abstract. The remaining 1020 manuscripts were reviewed in their entirety, and 133 were included in the Bayesian binomial random effect meta-analysis. The estimated rate of leiomyosarcomawas 0.51 per 1000 procedures (95%credible
interval (CrI) 0.16–0.98) or approximately 1 in 2000. Restricting the meta-analysis to the 64 prospective studies
resulted in a substantially lower estimate of 0.12 leiomyosarcomas per 1000 procedures (95 % CrI

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Informasi Detail

Judul Seri

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No. Panggil

Artikel

Penerbit

USA : Springer., 2015

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s10397-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Gynecol Surg (2015) 12:165–177

Subjek

Medicine
surgery
fibroids
prevalence
leiomyosarcoma

Info Detail Spesifik

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Pernyataan Tanggungjawab

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