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Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producingAcinetobactercalcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam

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Abstract Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolatedbetweenAugust2010andDecember2014fromthree large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and sevenfromhospitalC)thatwereNDM-1positive,andamong them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems. Genotyping indicated that NDM-1 carrying A. baumannii have expanded clonally in these hospitals. Five new STs (ST1135, ST1136, ST1137,
ST1138, and ST1139) were identified. One isolate carried NDM-1 on a plasmid belonging to the N-repA replicon type; no NDM-1-positive plasmids were identified in the other isolates. We have shown the extent of the carbapenem resistance and the local clonal spread of A. baumannii carrying NDM-1 inthesehospitals;coexistenceofNDM-1andIMP-1isreported for the first time from Vietnam here, and this will further seriously limit future therapeutic options

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Informasi Detail

Judul Seri

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No. Panggil

artikel

Penerbit

USA : Springer., 2016

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

DOI 10.1007/s10096-0

Klasifikasi

NONE

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Eur J Clin Microbiol Infect Dis

Subjek

Medicine
Acinetobactercalcoaceticus

Info Detail Spesifik

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Pernyataan Tanggungjawab

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