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Abstract Climate change particularly aects the health of vulnerable groups, such as children, the elderly, and socially disadvantaged individuals. Asthmatics are also at greater risk from the results of climate change due to their non-specic and allergen- specic bronchial hyperreactivity. Climate change aects the production, release, and number of allergenic pollens throughout Europe. Tre…
Most studies on the prevalence of food allergy report regional data. Pan-European multicenter cross-sectional studies on the prevalence of food allergies such as investigated within the framework of the EuroPrevall project are unfortunately not yet published. Based on published data, however, allergies to fruits and vegetables are among the most prevalent in food allergies in adolescence and ad…
Abstract Background: e basophil activation test (BAT) represents a sensitive test method that is available for the detection of sensitization to rye and wheat our in bakers with obstructive allergic airway disease. Since ImmunoCAP® failes to detect specic immunoglobulin E (IgE) in a part of the investigat- ed bakers with airway disease, BAT should be used as an additional research method. …
Anaphylaxis is an acute-onset, life- threatening, systemic hypersensitivity reaction. e acute reaction occurs due to a permanently immu- nologically altered response, which can result in mild to severe reactions and, in isolated cases, to fa-tal reactions upon allergen contact. e avoidance strategies required lifelong in aected individuals signicantly impair quality of life.
Sphingolipids are essential molecules of the mammalian epidermis. Keratinocytes generate and secrete huge amounts of ceramide-precursors to the extracellular domain of the stratum corneum, where they are further metabolized to speci c ceramide species. e arrangement of ceramides to well-organized lipid lamellae is essential to form the epidermal barrier. Besides their role as structural com…
Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist e ects on platelet-activating factor (PAF). Under the tradenames Rupa n® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregardi…
At an incidence of 1:500, celiac disease (formerly sprue) is an important di erential diagnosis in patients with malabsorption, abdominal discomfort, diarrhea and food intolerances. Celiac disease can induce a broad spectrum of both gastrointestinal and extraintestinal symptoms, e.g. dermatitis herpetiformis (Duhring’s disease). A variety of oligoand asymptomatic courses (e.g. anemia, osteo…
Abstract Epidemiologic studies revealed a crucial role of the environment for the increased prevalence of allergic disorders. e microbiota as part of our immediate environment promotes immune diversity that facilitates a well-equilibrated balance between immunity and tolerance. Alterations of our symbiotic microbiota especially in early life is thought to play a fundamental role in dening sus…
Anaphylaxis is a potentially fatal, immediate hyper-sensitivity reaction. Mast cells and basophils, by elaborating vasoactive mediators and cytokines, are the main primary e ector cells of anaphylaxis. Mast cells have been identi ed in human heart between myocardial bers, perivascularly, in the adventitia, and in the arterial intima. Mast cells isolated from human heart tissue (HHMC) of…