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Diabetes mellitus can usually be reasonably well controlled on a day-to-day basis with modern drug regimens. Nonetheless, the risks of metabolic decompensation and iatrogenic hypoglycaemia remain close at hand. Life threatening hyperglycaemia – with or without ketosis – may be precipitated by intercurrent illness or interruption of antidiabetic therapy; new cases of diabetes frequentl…
Over the last 50 yr, changes in lifestyle have led to a dramatic increase in the prevalence of type 2 diabetes in virtually every society around the world. Reductions in physical activity, increases in dietary intake, and the aging of the population are key factors in bringing about this rapid change. The westernization of diet and of other aspects of lifestyle in developing countries has un…
The title of each chapter is in the form of a question—emphasizing, we believe, the considerable doubts and uncertainty that pervade clinical diabetology, despite significant scientific advances in our understanding of the disease. It is interesting that even how to diagnose diabetes remains controversial, and the first chapters discuss such issues, including the problems of impaired glu…
Over decades, there has been broad interest of ophthalmologists and diabetologists in diabetic retinopathy. Despite markedly improved prognosis for visual problems due to laser treatment and vitrectomy, diabetic retinopathy is still one of the leading causes of blindness worldwide. This book provides profound information about the newest developments in the diagnosis and treatment of diabe…
In 1994, the American Association of Clinical Endocrinologists (AACE) developed a System of Intensive Diabetes Self-Management. This system remains the centerpiece of the AACE Medical Guidelines for the Management of Diabetes Mellitus. A key component of the AACE system of care is a patient-physician contract, which maintains the preeminence of the patient-physician relationship and the …
The grading and staging of tumors are routinely performed during the work-up of most patients who have cancer.Whereas the staging of tumors relies on a wealth of clinical, intraoperative, or radiologic data, tumor grading remains in the domain of pathologists—hence, the idea to compile a book for our colleagues in diagnostic surgical pathology and their residents. Like most surgical path…
The patient was in his usual state of health until the first week in July, 5 weeks before admission, when fevers led to body temperatures up to 39.4°C and neck stiffness developed. He saw his primary care physician, who noted thrombocytopenia; a viral illness was diagnosed, and antibiotics were administered. The fevers resolved within 5 days after they started, and the platelet count retur…
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The
Cytotoxic drugs, hormones, antihormones, and biologic agents have become increasingly effective means of treating cancer. Many patients are treated on protocols to provide optimal therapy for refractory or poorly responsive malignancies. Treatment may be inadequate or ineffective because of drug resistance of the tumor cells. This has been attributed to spontaneous genetic mutations in subpo…