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Abstract It has been long since French physician Jean-Baptiste Denys carried out the first successful blood transfusion to a human being. Using bird feathers as canules, sheep blood was transfused to a young man. The patient died soon after Denys' treatment and Denys was accused of murder. In the XXI century, known as the biotechnology century, we face new challenges in Medicine. New emerging …
Abstract One of the most spectacular advances in the history of scientific knowledge was the discovery of deoxyribonucleic acid (DNA) by Watson and Crick in 1953. This enabled certain proteins to be prepared in this way for their therapeutic use in clinical practice. Today, in the first decade of the 21st century, hundreds of therapeutic proteins have been produced recombinantly and about 50 …
Abstract Introduction: Lactic acidosis often occurs in severely unwell patients presenting to Accident and Emergency. It is commonly associated with either hypoxia or decreased tissue perfusion secondary due to cardiovascular collapse or sepsis. Case presentation: We present a case of severe lactic acidosis in the presence of normal tissue perfusion and oxygenation in a 31-year-old patient…
AbstractThis paper provides an overview of microswitch-based programs for persons with multiple disabilities. Three types of programs are included in the overview: Firstly, pro-grams involving only one microswitch, aimed at promoting specific response engagement in relation to contingent envi-ronmental stimulation; secondly, programs involving one or two microswitches, directed at promoting res…
Opinion StatementMany individuals with autism spectrum disorder and intellectual disability are candidates for augmen-tative and alternative communication (AAC). We review two current trends in AAC research involving persons with ASD and intellectual disability. The first trend is the use of smartphone and tablet devices in AAC interventions. The second trend is the direct comparison of the rel…
AbstractAutism spectrum disorder (ASD) is a heteroge-neous clinical condition whose prevalence has grown consid-erably during the last decade. Genetic factors are thought to underpin the disorder, but common genetic variants and epi-genetic mechanisms have been increasingly called into ques-tion for the majority of ASD cases. Growing prenatal expo-sure to new environmental toxicants has been sh…
Abstract Neuroimaging studies of attention-deficit/hyperac-tivity disorder (ADHD) are continuously adding to our knowl-edge on the neurobiology of this condition. Here, we update previous narrative and systematic reviews on the neuroimag-ing of ADHD, focusing on studies published in 2013. In order to comprehensively retrieve all the published studies, we searched a broad range of electronic dat…