Background & ObjectivesDengue is a climate-sensitive in-fectious disease. Climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveil-lance and control. Scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. This study aims to re-view the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based dengue earlywarning system in a dengue-endemic country, taking Malaysia as a case study. MethodWe reviewed the relationship between climate and
dengue derived from statistical modeling, laboratory tests,
and field studies. We searched electronic databases including PubMed, Scopus, EBSCO (MEDLINE), Web of Science, and the World Health Organization publications, and assessed cli-mate factors and their influence on dengue cases, mosquitoes, and virus and recent development in the field of climate and dengue. Results & DiscussionFew studies in Malaysia have empha-sized the relationship between climate and dengue. Climatic factors such as temperature, rainfall, and humidity are associ-ated with dengue; however, these relationships were not con-sistent. Climate change projections for Malaysia show a mounting risk for dengue in the future. Scientific studies on climate and dengue enhance dengue surveillance in the long run. ConclusionIt is essential for institutions in Malaysia to pro-mote research on climate and vector-borne diseases to ad-vance the development of climate-based early warning sys-tems. Together, effective strategies that improve existing re-search capacity, maximize the use of limited resources, and promote local-international partnership are crucial for sustain-ing research on climate and health.