This comprehensive text and reference comprises sixteen chapters dedicated to the main organ systems of
the body and their responses to toxic injury. The authors are all practising toxicological pathologists from
academia and research laboratories with an international reputation in their field. The adoption of the
classical approach to target organ toxicity was influenced by the specific, and sometimes unique, manner in
which compounds manifest toxic injury. Each chapter therefore addresses the normal anatomy and
physiology of the given organ system before detailing the morphological and pathophysiological events
leading to toxic injury. It is this integration of altered form and function that defines the processes of target
organ toxicity, the cornerstone of understanding hazard and hence risk and safety assessment. The practising
toxicologist needs to receive from the pathologist a lucid appreciation of the likely clinical impact of the toxic
changes observed; first in the test species and then, by extrapolation, to man. The information provided in
each chapter is directed at understanding the underlying processes of toxicity involved. An appreciation of
the significant species differences in the toxic manifestations to these processes is an essential factor in the
effective extrapolation of animal test data to the human clinical environment.