AbstractThe exposome concept takes a holistic approach facilitated by new and emerging technologies to describe ‘the totality of human environmental (i.e. non-genetic) expo-sures from conception onwards, complementing the genome’. It provides a framework to advance the environmental epide-miology field that has until now focused almost exclusively on single-exposure health effects. The exposome includes an external domain, measured by methods including geo-spatial modelling, questionnaire and biomonitoring of external expo-sures while the internal domain is commonly assessed through molecular omics platforms. The internal domain, in part, re-flects the biological response to the external domain. New statistical frameworks are required to integrate and assess exposome-health effects. The pregnancy period is a key starting point to describe the dynamic exposome, due to its heightened sensitivity and potential lifetime impact. Ahandful of studies have started to move towards an exposome ap-proach in assessing the effects of the multiple exposures dur-ing pregnancy on child development. New research projects are underway to test the exposome approach on a large scale. Keywords Exposome.Child health.Pregnancy. Multi-pollutant. Omics.Exposure