AbstractThe evolutionary conservation of genomic, biochem-ical, and developmental features between zebrafish andhumans is gradually coming into focus, with the end result that the zebrafish embryomodel has emerged as a powerful tool for uncovering the effects of environmental exposures on a multitude of biological processes with direct relevance to human health. In this review, we highlight advances in automation, high-throughput screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in our understanding of how chemicals in our environment affect our health and wellbeing. Keywords Zebrafish embryomodel. High-throughput screening .Environmental exposure.Human health