Abstracts
Background:To investigate the Cochleo-vestibular clinical and audiometric findings in Multi and Extreme Drug Resistance(MDR and XDR) tuberculosis(TB) patients on treatment and make recommendations.
Methods:A cross-sectional study of adult MDR and XDR-TB patients was conducted in a general hospital in Cape-Town-South-Africa. Ethical approval was secured and all consenting patients administered with pretested and validated questionnaire under the guidance of International Classification of Functioning, Disability and Health(ICF) Checklist-version-2.1a. Audiometric evaluation included: Otoscopy, Diagnostic Audiometry and Tympanometry. The
data analyses were done with SPSS version 16, Chi-square and StatCalc-7.
Results:Fifty-three adults, ages 18-60 (mean-33 years) comprising 26 males and 27 females participated in the
study. Hospital stay duration varied from 1-18 months (mean-6 months) and all were on anti-Koch’s second line drugs (regimen 2). MDR TB group were 45(85%) and XDR 8(15%). Vertigo was the most common vestibular symptoms, 24(45%) whereas, tinnitus 23(42%) and hearing loss 13(25%) were most frequent auditory complaints. Bilateral sensorineural hearing losses of varying degrees were confirmed in 23(47%). There was no association between gender and age with hearing loss [c 2 (P = 0.16, ά= 0.05) and (p = 0.13,ά= 0.05)]. Furthermore, MDR and XTR TB groups [20/42 Vs 3/8; Z = 0.46 and P = 0.64], showed no difference in pattern of the hearing losses.
Conclusions:A multi-disciplinary close surveillance of MDR and XDR TB patients on therapy is imperative. Finally,
researches into therapeutic trials on antidotes and potent safer substitutes for aminoglycosides in the management
are recommended.
Keywords:Multidrug resistance, Extreme drug resistance, Aminoglycosides, ototoxicity