AbstractPersistent organic pollutants (POPs) are environ-mental chemicals that persist in the environment for long periods of time. The UN, under the Stockholm Convention, has regulated many of these POPs. However, because of their long half-lives, human exposure persists for decades even after production has been stopped. The health effects are varied and range from skin rashes to developmental delays to cancer, depending on the level of exposure. This review is meant as a primer for practicing clinicians to help identify acute exposure, to provide guidance to questioning patients, and be well-informed with regards to policy changes. It touches upon human exposure, current regulations, and health effect of the persistent organic pollutants, including: dioxin, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD), and the endocrine disruptor bisphenol A (BPA). Keywords Persistent organic pollutants. POPs.Dioxin. Polychlorinated biphenyl ethers. PCBs. Polybrominated diphenyl ethers. PBDEs.Hexabromocyclododecane. HBCD.Bisphenol A.BPA.Stockholm Convention