AbstractThe brain-gut-microbiome axis refers to the inter-actions between the central nervous system, gastrointestinal (GI) system, and microorganisms that live in the gastrointes-tinal tract. Exploring these interactions provides a rationale for why gastrointestinal disorders commonly occur in children with autism spectrum disorders (ASD). Signs of altered brain-gut interactions that are closely associated with func-tional GI disorders (FGIDs) commonly occur in children with ASD. Studies of microbiome in ASD suggest that changes in the gut microbiome may be associated with ASD and with GI disorders in children with ASD. Further studies into the brain-gut-microbiome axis could lead to new techniques for identi-fying GI disorders in children with ASD and novel therapies for treating ASD behaviors. Keywords Brain-gut axis.Central nervous system. Developmental disorders. Autismspectrumdisorders.ASD. GIdisorders. FunctionalGIdisorders.Gutmicrobiome.ASD behaviors.Review