AbstractThe effects of prenatal alcohol use have been well documented. In this review, we discuss the inclusion of Neu-robehavioral Disorder Associated with Prenatal Alcohol Ex-posure (ND-PAE) as a condition for further study in theDi-agnostic and Statistical Manual of Mental Disorders-Fifth Edition(DSM-5). We present a review of the evidence for impairment in three domains highlighted in ND-PAE: neurocognitive functioning, self-regulation, and adaptive functioning. In addition, we provide guidelines for clinical assessment of each domain. When considering ND-PAE, it is essential to obtain as comprehensive an assessment as pos-sible, including multidisciplinary/multimethod assessment of the individual by a qualified team. It is our aim to provide clinicians with a useful reference for assessing ND-PAE and highlight important guidelines to be followed when conducting neuropsychological assessment. KeywordsFetal alcohol syndrome (FAS). Fetal alcohol spectrumdisorders. Diagnosis.Prenatal alcohol exposure. Neuropsychological testing. Assessment