Rupatadine is a modern non-sedating H1-antihistamine that also haswith additional antagonist e ects
on platelet-activating factor (PAF). Under the tradenames Rupa n® and Urtimed®, Rrupatadine is approvedregistered in Germany for the treatment of allergic rhinitis and urticaria infor adults and children aged over 12 years. In this review, the available literature available to date onregarding the pharmacological pro le and clinical application of Rrupatadine is reviewed and compared to other conventional histamines. In conclusionFinally, the side e ects, safety and interaction pro leincompatibility of Rrupatadine are discussed. Due to CYP p450 metabolism, Rrupatadine should not be given together with Eerythromycin, Kketoconazole or grapefruit juice. Rupatadine has been found to be e ective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as e ective and safe.