Abstract e term α-Gal syndrome describes a novel IgE-me-diated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classication
as a syndrome is proposed on the basis of its clini-cal relevance in three dierent elds of allergy: food, drugs, and tick bites. e main focus of the present article is on α-Gal as an eliciting allergen in food allergy. It was recently shown that immediate-type allergies to pork kidney and other mammalian in-nards belong to the spectrum of α-Gal syndrome. ese allergic reactions manifest as classic immedi-ate-type allergies with a typical latency of under 1 h. e phenomenon of a delayed-onset immediate-type allergy with a latency of 3–6 h following inges-tion of mammalian meat is considered pathogno-monic for α-Gal syndrome. is clinically distinct type of presentation can be explained using the con-cept of food-dependent exercise-induced anaphy-laxis (FDEIA). However, clinical observations and challenge testing in this constellation reveal that in-dividual sensitivity in α-Gal patients is highly vari-able and which broadens our basic understanding of α-Gal syndrome