Abstract  e term autoallergy denotes autoimmunity accom-panying an atopic disease, with antigen-speci c IgE as a hallmark.  is phenomenon is discussed to contribute to a chroni cation of the disease and to shape the immune response inchronic atopic der matitis (AD). In this review, we highlight recent in-sights into the autoallergic in ammation in AD. Di erent mechanisms underlying the allergenicity of autoallergens are discussed at the moment:in-trinsic functions modulating the immune system as well as molecular mimicry may in uence the aller-genic potential of these proteins. Finally, the role of speci c T cells is discussed.