Abstract One recent innovation in the field of gynecology is laparoendoscopic single-site surgery (LESS). It is associated with reduced postoperative pain and better cosmetic outcome. The present paper aims to explain techniques and instrumen-tations associated with single-port hysterectomies. A retro-spective case-control study is included, comparing LESSwith conventional four-port hysterectomies to highlight the feasi-bility of LESS. This study involved literature search and per-sonal experience regarding single-port hysterectomy and a retrospective case-control study of 34 patients who underwent supracervical hysterectomy between April 2011 and Novem-ber 2012. Operating time, blood loss, and length of hospital staywere similar in the two groups. Patient’s evaluation of the cosmetic result was in favor of LESS, however not significant. LESS represents a new frontier inminimally invasive surgery. New instrumentation and recommendations have been devel-opedwhich are expected tomake the technique more feasible. This study demonstrates that LESS supracervical hysterecto-my has comparable operative outcomes to conventional lapa-roscopic hysterectomy and is a feasible approach for supracervical hysterectomy. Based on the literature and our
experience, a feasible step by step technique for surgeons who are interested in performing supracervical LESS hysterectomy is described. Comparative data and prospective trials are required in order to determine the clinical utility and
impact of LESS in treatment of gynecological conditions in the future.